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One of the most successful threads I've started on the Hero Boards was a thread entitled “Help Me Populate A Creepy Hotel.” The board members came up with the eeriest cast of characters you've seen this side of Charles Addams' cartoons. I got the idea from an RPG.net thread that was also extremely good. My original introduction still works well for it:
“… Imagine a hotel stocked with weird characters. They should be strange in a Twin Peaks/X-Files kind of way - they can be possibly vaguely slightly mystical (but it should never be obviously magic), or they could be vaguely slightly high-tech (in a conspiracy sort of easily-mistaken-for-something-else way), or whatever you like. The only requirement should be that they are weird characters easily captured in a few sentences. You don't have to give them names - giving them titles such as, er, Cat Piss Man or Dog Blood Man makes it easier to put them in any other game.”
It can be decor, people, events, other things. It's cooler for the GM if there is an actual reason for the wierdness, even if the players never are told what it is.